Which of the following factors is likely to worsen insulin sensitivity?

Increased body weight is known to have a negative impact on insulin sensitivity. As body weight increases, especially due to excess fat accumulation, particularly visceral fat, the body's ability to utilize insulin effectively diminishes. This is largely due to the fact that excess adipose tissue can produce substances that induce a state of inflammation and lead to insulin resistance. Insulin resistance means that a higher amount of insulin is required to achieve the same metabolic effects that a smaller amount of insulin would normally provide.

On the other hand, regular physical activity, low body weight, and a balanced diet typically promote better insulin sensitivity. Physical activity enhances glucose uptake by the muscles and improves insulin action. Maintaining a low body weight reduces the burden of excess fat on the body, creating a more favorable metabolic state. Similarly, a balanced diet that is rich in nutrients and low in processed sugars and unhealthy fats supports overall metabolic health, improving insulin sensitivity rather than worsening it.